Creative Biolabs has over 10 years of experience in computational structural biology and antibody engineering that has developed a fully-comprehensive computer-aided antibody development PreciAb™ platform made up of an all-around set of technologies and proprietary algorithms for specifically defined antibody design.

Creative Biolabs has been recognized as the leading role in improving antibody engineering with the customer-centered one-stop services and frontier science and technology. To help clients from all over the world solve problems encountered when working on the antibodies that are the binding proteins with broad application prospects and research meanings, Creative Biolabs launches the cGMP certified PreciAb™ platform.

Featured services to be operated on PreciAb™ platform related to antibody design include but are not confined to:

1．Antibody Structure Modeling

Customized antibody structure modeling services are offered by means of computational modeling approaches aiming at assisting customers with predicting antibody 3-D structure and hence enhance clients’ projects’ process. Services mainly cover homology antibody modeling, loop structure refinement, modeling of the framework regions, side chain modeling, antibody modeling assessment. PreciAb™ platform penetrates through the entitle pipeline of antibody structure modeling services to enhance efficiency and cut time.

2．Computer-aided Affinity Maturation

Affinity maturation stands for operating the antibody variable region for the purpose to introduce point mutations in the framework and CDR loops to select for a variant with improved binding affinity for its target. PreciAb™ platform is inevitably involved in the in silicoaffinity maturation services provided by Creative Biolabs, through thorough optimization techniques that exhaustively rank-order the best solutions in a discretized search space. It helps clients triumph over challenges, assists in achieving high-affinity bindings that contribute to amplifying dissociation half-times, expanding detection limits, reducing drug dosages, as well as improving drug efficacy.

In the PreciAb™ platform, antibody development steps are proceeded systematically following the orders below.

1．Construction antibody structure by combining structure and homology-based modeling methods,

2．Structure optimization by dynamics simulation, rotamer library, loop modeling,

3．CDR identification based upon 3D antibody structure,

4．Antibody-antigen complex modeling and interaction analysis,

5．Paratope & epitope identification pluses key residues analysis,

6．In silico affinity maturation and function modification,

7．Global analysis and optimization of antibody biophysical properties (thermodynamic stability, aggregation propensity, immunogenicity).

Creative Biolabs is always adhering to the ideas that customers are the orientation. Holding experience of years of exploration and under the assistance of a group of expertise in relevant area, the PreciAb™ platform can guarantee satisfactory results about antibody design & engineering. More details can be referred to at https://www.creative-biolabs.com/preciab/.

About Creative Biolabs

Creative Biolabs is the leading custom service provider with affluent experience in various antibody production and engineering fields. Major service portfolio includes mouse and rat monoclonal antibody production utilizing hybridoma technology, human, monkey, rabbit, chicken, dog, llama and camel monoclonal antibody production through various antibody library technologies (including phage display, bacterial display and yeast display).